MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
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چکیده
منابع مشابه
Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells.
We presently demonstrate that histone deacetylase inhibitors (HDACIs) enhance toxicity of melanoma differentiation-associated gene-7/interleukin 24 (mda-7/IL-24) in invasive primary human glioblastoma multiforme (GBM) cells. Additionally, a method is described to augment the efficacy of adenoviral delivery of mda-7/IL-24 in these cells. HDACIs synergized with melanoma differentiation-associated...
متن کاملPrimary pigmented intraocular tumors in animals.
Intraocular melanomas, among the most com mon eye tumors in man, have seldom been reported in animals. This is particularly surprising in regard to the dog, a species that usually lives well into the "tumor age" and is affected by diverse neoplasms. In his "Pathology of Tumours" (1953) Willis (48) stated : ' 'I have not read of an intraocular melano ma in an animal." While reported cases are no...
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BACKGROUND Primary cilia are non-motile sensory cytoplasmic organelles that are involved in cell cycle progression. Ultrastructurally, the primary cilium region is complex, with normal ciliogenesis progressing through five distinct morphological stages in human astrocytes. Defects in early stages of ciliogenesis are key features of astrocytoma/glioblastoma cell lines and provided the impetus fo...
متن کاملDepressed Cell-mediated Immunity in Patients with Primary Intracranial Tumors
Tumor immunity in patients with primary intracranial tumors was assessed in relation to the general status of host immunocompetence. Lymphocyte sensitization to tumor-specific membrane antigens was demonstrated by the proliferative response of lymphocytes in the presence of autochthonous tumor cells. Paradoxically, one-half of the patients could not be sensitized to a primary antigen, dinitroch...
متن کاملIntraocular tumors in animals. II. Primary nonpigmented intraocular tumors.
The present authors (14) have recently discussed intraocular tumors in animals, in a report restricted to primary pigmented neoplasms and based on fifteen such cases in dogs. This was the first comprehensive study of spontaneous intraocular tumors in animals, but because of its restricted scope there remain for consideration other primary and various secondary intraoeular tumors. In the present...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2008
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.7.6.5928